Update on New Antigens in the Pathogenesis of Membranous Nephropathy

Previously, membranous nephropathies were divided into primary and secondary categories when the exact mechanism or pathogenetic factor unknown. Approximately 70% accounted for nephropathies. The remaining 30% called because they developed due to well-known diseases such as autoimmune diseases, tumours, infections, drug assumptions. discoveries of M-type phospholipase A2 receptor thrombospondin type 1 domain containing 7A causative antigens in a part so-called opened new knowledge on effective causes large these diseases. availability novel techniques laser micro-dissection tandem mass spectrometry, well immunochemistry with antibodies directed against proteins, allowed confirmation involved. use confocal microscopy Western blot detection antigen glomerular membrane, same relative have been detected serum samples. Through techniques, four first detected, including neural epidermal growth semaphorin 3B nephropathy, exostosin 2 cell adhesion molecule lupus nephropathy. aim this study is describe characteristics discovered their association other In addition, are horizon, story nephropathy still be completely written understood.